STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCLS1Hematopoietic lineage cell-specific protein. (510 aa)    
Predicted Functional Partners:
WASL
Neural Wiskott-Aldrich syndrome protein.
   
 0.999
WAS
wiskott-Aldrich syndrome protein.
   
 0.985
SRC
Tyrosine-protein kinase.
   
 0.976
DNM2
Dynamin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
   
 0.976
ACTR2
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
   
 0.965
TJP1
LOW QUALITY PROTEIN: tight junction protein ZO-1; Belongs to the MAGUK family.
    
 0.950
ACTR3
Actin-related protein 3; Belongs to the actin family.
   
 0.933
ACTG1
LOW QUALITY PROTEIN: actin, cytoplasmic 2.
    
 0.933
ACTR3B
Actin-related protein 3B isoform X1; Belongs to the actin family.
   
 0.933
CTTN
Src substrate cortactin.
  
  
0.921
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.