STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IGF1RTyrosine-protein kinase receptor. (1405 aa)    
Predicted Functional Partners:
IGF1
Insulin-like growth factor I isoform X1.
    
 0.999
INS-IGF2
Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.983
PTPN1
Tyrosine-protein phosphatase non-receptor type.
   
 0.933
ESR1
LOW QUALITY PROTEIN: estrogen receptor.
    
 0.916
GRB10
Growth factor receptor-bound protein 10.
    
 0.868
IGF2R
Cation-independent mannose-6-phosphate receptor.
   
 
 0.862
INSR
Tyrosine-protein kinase receptor.
  
 
0.852
GRB14
Growth factor receptor-bound protein 14.
    
 0.844
ERBB2
Receptor protein-tyrosine kinase.
   
0.827
PTPN2
Tyrosine-protein phosphatase non-receptor type.
   
 0.760
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.