node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KDM1A | LOC110577892 | A0A2Y9GKZ9 | A0A2Y9GUW2 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Histone H2A; Belongs to the histone H2A family. | 0.907 |
KDM1A | LOC110578551 | A0A2Y9GKZ9 | A0A2Y9H394 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Histone H3; Belongs to the histone H3 family. | 0.926 |
KDM1A | LOC110578552 | A0A2Y9GKZ9 | A0A2Y9H135 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Histone H2B; Belongs to the histone H2B family. | 0.548 |
KDM1A | LOC110578855 | A0A2Y9GKZ9 | A0A2Y9GXV8 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Histone H2B type 2-F-like; Belongs to the histone H2B family. | 0.548 |
KDM1A | LOC110580915 | A0A2Y9GKZ9 | A0A2Y9H3T6 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.778 |
KDM1A | LOC110586611 | A0A2Y9GKZ9 | A0A2Y9HLC3 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Histone H2B; Belongs to the histone H2B family. | 0.811 |
KDM1A | LOC110586648 | A0A2Y9GKZ9 | A0A2Y9HLH7 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Histone H2B; Belongs to the histone H2B family. | 0.672 |
KDM1A | RCOR1 | A0A2Y9GKZ9 | A0A2Y9G941 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | REST corepressor 1. | 0.999 |
LOC110577892 | KDM1A | A0A2Y9GUW2 | A0A2Y9GKZ9 | Histone H2A; Belongs to the histone H2A family. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.907 |
LOC110577892 | LOC110578551 | A0A2Y9GUW2 | A0A2Y9H394 | Histone H2A; Belongs to the histone H2A family. | Histone H3; Belongs to the histone H3 family. | 0.908 |
LOC110577892 | LOC110578552 | A0A2Y9GUW2 | A0A2Y9H135 | Histone H2A; Belongs to the histone H2A family. | Histone H2B; Belongs to the histone H2B family. | 0.944 |
LOC110577892 | LOC110578855 | A0A2Y9GUW2 | A0A2Y9GXV8 | Histone H2A; Belongs to the histone H2A family. | Histone H2B type 2-F-like; Belongs to the histone H2B family. | 0.946 |
LOC110577892 | LOC110580915 | A0A2Y9GUW2 | A0A2Y9H3T6 | Histone H2A; Belongs to the histone H2A family. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.863 |
LOC110577892 | LOC110586611 | A0A2Y9GUW2 | A0A2Y9HLC3 | Histone H2A; Belongs to the histone H2A family. | Histone H2B; Belongs to the histone H2B family. | 0.954 |
LOC110577892 | LOC110586648 | A0A2Y9GUW2 | A0A2Y9HLH7 | Histone H2A; Belongs to the histone H2A family. | Histone H2B; Belongs to the histone H2B family. | 0.944 |
LOC110577892 | MYSM1 | A0A2Y9GUW2 | A0A2Y9GP04 | Histone H2A; Belongs to the histone H2A family. | Histone H2A deubiquitinase MYSM1. | 0.915 |
LOC110577892 | RCOR1 | A0A2Y9GUW2 | A0A2Y9G941 | Histone H2A; Belongs to the histone H2A family. | REST corepressor 1. | 0.883 |
LOC110577892 | SMARCB1 | A0A2Y9GUW2 | A0A2Y9GWA1 | Histone H2A; Belongs to the histone H2A family. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. | 0.876 |
LOC110578551 | KDM1A | A0A2Y9H394 | A0A2Y9GKZ9 | Histone H3; Belongs to the histone H3 family. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.926 |
LOC110578551 | LOC110577892 | A0A2Y9H394 | A0A2Y9GUW2 | Histone H3; Belongs to the histone H3 family. | Histone H2A; Belongs to the histone H2A family. | 0.908 |