node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHFR | FPGS | A0A2Y9HUG9 | A0A2Y9H599 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.958 |
DHFR | GGH | A0A2Y9HUG9 | A0A2Y9GXB3 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Folate gamma-glutamyl hydrolase. | 0.944 |
DHFR | MTHFD1 | A0A2Y9HUG9 | A0A2Y9HZP9 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | C-1-tetrahydrofolate synthase, cytoplasmic. | 0.934 |
DHFR | MTHFD1L | A0A2Y9HUG9 | A0A2Y9HHB8 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1. | 0.943 |
DHFR | MTHFD2 | A0A2Y9HUG9 | A0A2Y9HTH2 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial. | 0.714 |
DHFR | MTHFD2L | A0A2Y9HUG9 | A0A2Y9I245 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2. | 0.714 |
DHFR | SHMT1 | A0A2Y9HUG9 | A0A2Y9HEG8 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.961 |
DHFR | SHMT2 | A0A2Y9HUG9 | A0A2Y9GYS7 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.958 |
DHFR | TYMS | A0A2Y9HUG9 | A0A2Y9GRT1 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthase. | 0.998 |
FPGS | DHFR | A0A2Y9H599 | A0A2Y9HUG9 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.958 |
FPGS | GGH | A0A2Y9H599 | A0A2Y9GXB3 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Folate gamma-glutamyl hydrolase. | 0.944 |
FPGS | MTHFD1 | A0A2Y9H599 | A0A2Y9HZP9 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | C-1-tetrahydrofolate synthase, cytoplasmic. | 0.947 |
FPGS | MTHFD1L | A0A2Y9H599 | A0A2Y9HHB8 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1. | 0.945 |
FPGS | MTHFD2 | A0A2Y9H599 | A0A2Y9HTH2 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial. | 0.929 |
FPGS | MTHFD2L | A0A2Y9H599 | A0A2Y9I245 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2. | 0.929 |
FPGS | NUDT15 | A0A2Y9H599 | A0A2Y9H760 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Nucleotide triphosphate diphosphatase NUDT15. | 0.937 |
FPGS | SHMT1 | A0A2Y9H599 | A0A2Y9HEG8 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.945 |
FPGS | SHMT2 | A0A2Y9H599 | A0A2Y9GYS7 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.934 |
FPGS | TYMS | A0A2Y9H599 | A0A2Y9GRT1 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase. | 0.943 |
GGH | DHFR | A0A2Y9GXB3 | A0A2Y9HUG9 | Folate gamma-glutamyl hydrolase. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.944 |