STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC110586611Histone H2B; Belongs to the histone H2B family. (126 aa)    
Predicted Functional Partners:
LOC110586608
Histone H3; Belongs to the histone H3 family.
 
 
 0.998
LOC110572105
Histone H2A; Belongs to the histone H2A family.
   
 0.989
LOC110592591
Histone H2A; Belongs to the histone H2A family.
   
 0.989
LOC110577892
Histone H2A; Belongs to the histone H2A family.
 
 0.954
LOC110580854
Histone H2A; Belongs to the histone H2A family.
 
 0.943
LOC110586609
Histone H2A; Belongs to the histone H2A family.
 
 0.943
LOC110578551
Histone H3; Belongs to the histone H3 family.
 
 
 0.928
LOC110580915
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 0.876
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
 
 0.859
HDAC8
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
    
 0.831
Your Current Organism:
Neomonachus schauinslandi
NCBI taxonomy Id: 29088
Other names: Hawaiian monk seal, Monachus schauinslandi, N. schauinslandi
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.