STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hisCDPutative histidine biosynthesis bifunctional protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa)    
Predicted Functional Partners:
hisB
Histidine biosynthesis bifunctional protein; In the N-terminal section; belongs to the histidinol- phosphatase family.
 
 0.999
hisH
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
 0.999
hisCD-2
Putative histidine biosynthesis bifunctional protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 0.998
hisF
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.998
hisI
Histidine biosynthesis bifunctional protein; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.998
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.996
hisA1
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino imidazole-4-carboxamide isomerase.
  
 0.989
hisA2
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino imidazole-4-carboxamide isomerase 2.
 
  
 0.941
hutH
Histidine ammonia-lyase.
    
 0.920
hdc
Histidine decarboxylase (fragment).
     
 0.900
Your Current Organism:
Photorhabdus asymbiotica
NCBI taxonomy Id: 291112
Other names: ATCC 43950, CIP 106331, DSM 15149, P. asymbiotica, strain 3265-86
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