node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argI | carA | BPEN_032 | BPEN_126 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. | 0.882 |
argI | carB | BPEN_032 | BPEN_127 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | 0.962 |
argI | hisI | BPEN_032 | BPEN_484 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | phosphoribosyl-AMP cyclohydrolase; Bifunctional; ortholog to Escherichia coli bnum: b2026; MultiFun: Metabolism 1.5.1.16; phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.521 |
argI | ribD | BPEN_032 | BPEN_240 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Pyrimidine deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.668 |
carA | argI | BPEN_126 | BPEN_032 | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.882 |
carA | carB | BPEN_126 | BPEN_127 | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | 0.999 |
carA | folA | BPEN_126 | BPEN_128 | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.772 |
carA | glnA | BPEN_126 | BPEN_643 | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. | Glutamine synthetase; Ortholog to Escherichia coli bnum: b3870; MultiFun: Metabolism 1.5.1.2, 1.8.3. | 0.934 |
carA | guaA | BPEN_126 | BPEN_546 | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.512 |
carA | guaB | BPEN_126 | BPEN_547 | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.493 |
carA | ribD | BPEN_126 | BPEN_240 | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. | Pyrimidine deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.400 |
carB | argI | BPEN_127 | BPEN_032 | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.962 |
carB | carA | BPEN_127 | BPEN_126 | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | Carbamoyl-phosphate synthase, small chain; Ortholog to Escherichia coli bnum: b0032; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; Belongs to the CarA family. | 0.999 |
carB | dapF | BPEN_127 | BPEN_600 | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.860 |
carB | folA | BPEN_127 | BPEN_128 | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.773 |
carB | glnA | BPEN_127 | BPEN_643 | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | Glutamine synthetase; Ortholog to Escherichia coli bnum: b3870; MultiFun: Metabolism 1.5.1.2, 1.8.3. | 0.937 |
carB | guaA | BPEN_127 | BPEN_546 | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.830 |
carB | guaB | BPEN_127 | BPEN_547 | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.712 |
carB | hisI | BPEN_127 | BPEN_484 | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | phosphoribosyl-AMP cyclohydrolase; Bifunctional; ortholog to Escherichia coli bnum: b2026; MultiFun: Metabolism 1.5.1.16; phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.643 |
carB | polA | BPEN_127 | BPEN_645 | Carbamoyl-phosphate synthase, large chain; Ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.599 |