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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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filled nodes:
a 3D structure is known or predicted
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cysGMultifunctional siroheme synthase: uroporphyrinogen methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (474 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.994
cysC
Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate.
  
  
 0.992
cysI
Sulfite reductase, beta subunit, NADPH-dependent hemoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.988
hemD
Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.977
cysD
ATP-sulfurylase, subunit 2; Ortholog to Escherichia coli bnum: b2752; MultiFun: Metabolism 1.8.2; ATP:sulfate adenylyltransferase.
  
  
 0.976
cysH
3'-phosphoadenosine 5'-phosphosulfate (PAPS) reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.966
cysN
ATP-sulfurylase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
  
  
 0.930
cysJ
Sulfite reductase, alpha subunit (flavoprotein); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
  
  
 0.904
cysK
Cysteine synthase A; Ortholog to Escherichia coli bnum: b2414; MultiFun: Metabolism 1.5.1.12; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
  
 0.766
hisC
Histidinol-phosphate aminotransferase; Ortholog to Escherichia coli bnum: b2021; MultiFun: Metabolism 1.5.1.16; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 0.756
Your Current Organism:
Blochmannia pennsylvanicus
NCBI taxonomy Id: 291272
Other names: C. Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus BPEN, Candidatus Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus strain BPEN
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