| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dnaN | nrdA | BPEN_015 | BPEN_494 | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside diphosphate reductase 1, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.689 |
| dnaN | yqgE | BPEN_015 | BPEN_258 | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | 0.495 |
| grxC | nrdA | BPEN_628 | BPEN_494 | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | Ribonucleoside diphosphate reductase 1, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.938 |
| grxC | yqgE | BPEN_628 | BPEN_258 | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | 0.759 |
| hflC | hflK | BPEN_085 | BPEN_084 | HflC; HflC and HflK could regulate a protease. | HflK; HflC and HflK could encode or regulate a protease. | 0.996 |
| hflC | nuoCD | BPEN_085 | BPEN_507 | HflC; HflC and HflK could regulate a protease. | NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. | 0.816 |
| hflC | yqgE | BPEN_085 | BPEN_258 | HflC; HflC and HflK could regulate a protease. | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | 0.408 |
| hflK | hflC | BPEN_084 | BPEN_085 | HflK; HflC and HflK could encode or regulate a protease. | HflC; HflC and HflK could regulate a protease. | 0.996 |
| hflK | nuoCD | BPEN_084 | BPEN_507 | HflK; HflC and HflK could encode or regulate a protease. | NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. | 0.816 |
| hflK | yqgE | BPEN_084 | BPEN_258 | HflK; HflC and HflK could encode or regulate a protease. | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | 0.408 |
| nrdA | dnaN | BPEN_494 | BPEN_015 | Ribonucleoside diphosphate reductase 1, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.689 |
| nrdA | grxC | BPEN_494 | BPEN_628 | Ribonucleoside diphosphate reductase 1, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | 0.938 |
| nrdA | yqgE | BPEN_494 | BPEN_258 | Ribonucleoside diphosphate reductase 1, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | 0.971 |
| nuoCD | hflC | BPEN_507 | BPEN_085 | NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. | HflC; HflC and HflK could regulate a protease. | 0.816 |
| nuoCD | hflK | BPEN_507 | BPEN_084 | NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. | HflK; HflC and HflK could encode or regulate a protease. | 0.816 |
| nuoCD | yqgE | BPEN_507 | BPEN_258 | NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | 0.436 |
| tdk | yqgE | BPEN_447 | BPEN_258 | Thymidine kinase; Ortholog to Escherichia coli bnum: b1238; MultiFun: Metabolism 1.7.33. | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | 0.400 |
| yqgE | dnaN | BPEN_258 | BPEN_015 | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.495 |
| yqgE | grxC | BPEN_258 | BPEN_628 | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | 0.759 |
| yqgE | hflC | BPEN_258 | BPEN_085 | Putative transcriptional regulator; Ortholog to Escherichia coli bnum: b2948; Belongs to the UPF0301 (AlgH) family. | HflC; HflC and HflK could regulate a protease. | 0.408 |