| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cdsA | dxr | BPEN_285 | BPEN_283 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | 0.782 |
| cdsA | ecfE | BPEN_285 | BPEN_286 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | Putative membrane protein; Ortholog to Escherichia coli bnum: b0176; MultiFun: Cell processes 5.5; Cell structure 6.1; Regulation 3.1.3.4. | 0.875 |
| cdsA | fabZ | BPEN_285 | BPEN_290 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.476 |
| cdsA | frr | BPEN_285 | BPEN_282 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.485 |
| cdsA | hlpA | BPEN_285 | BPEN_288 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | Histone-like protein; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | 0.570 |
| cdsA | lpxA | BPEN_285 | BPEN_291 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | UDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.482 |
| cdsA | lpxD | BPEN_285 | BPEN_289 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.650 |
| cdsA | pyrH | BPEN_285 | BPEN_281 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.618 |
| cdsA | uppS | BPEN_285 | BPEN_284 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.985 |
| cdsA | yaeT | BPEN_285 | BPEN_287 | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | Outer membrane protein precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. | 0.692 |
| dxr | cdsA | BPEN_283 | BPEN_285 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | Phosphatidate cytidylyltransferase; Ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; Belongs to the CDS family. | 0.782 |
| dxr | ecfE | BPEN_283 | BPEN_286 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | Putative membrane protein; Ortholog to Escherichia coli bnum: b0176; MultiFun: Cell processes 5.5; Cell structure 6.1; Regulation 3.1.3.4. | 0.660 |
| dxr | fabZ | BPEN_283 | BPEN_290 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.420 |
| dxr | frr | BPEN_283 | BPEN_282 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.709 |
| dxr | hlpA | BPEN_283 | BPEN_288 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | Histone-like protein; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | 0.430 |
| dxr | lpxA | BPEN_283 | BPEN_291 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | UDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.422 |
| dxr | lpxD | BPEN_283 | BPEN_289 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.460 |
| dxr | pyrH | BPEN_283 | BPEN_281 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.645 |
| dxr | uppS | BPEN_283 | BPEN_284 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.951 |
| dxr | yaeT | BPEN_283 | BPEN_287 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). | Outer membrane protein precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. | 0.492 |