Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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sdhCSuccinate dehydrogenase cytochrome b-556 subunit; Ortholog to Escherichia coli bnum: b0721; MultiFun: Cell structure 6.1; Metabolism 1.3.4, 1.3.6, 1.4.1, 1.4.3, 1.6.15.1. (135 aa)    
Predicted Functional Partners:
sdhD
Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
 
 0.999
sdhA
Succinate dehydrogenase catalytic and flavoprotein subunit; Ortholog to Escherichia coli bnum: b0723; MultiFun: Metabolism 1.3.4, 1.3.6, 1.4.1; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.999
sdhB
Succinate dehydrogenase iron-sulfur protein; Ortholog to Escherichia coli bnum: b0724; MultiFun: Metabolism 1.3.4, 1.3.6, 1.4.1.
 
 0.999
sucC
succinyl-CoA synthetase, beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.996
nuoCD
NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
   
 
 0.990
sucD
succinyl-CoA synthetase, alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.986
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 
 0.943
sucA
2-oxoglutarate dehydrogenase E1 component; Ortholog to Escherichia coli bnum: b0726; MultiFun: Metabolism 1.3.4.
  
  
 0.937
cyoA
Cytochrome o ubiquinol oxidase, subunit II; Ortholog to Escherichia coli bnum: b0432; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2; Transport 4.3.D.4, 4.S.82.
   
 
 0.843
aspC
Aspartate aminotransferase; Ortholog to Escherichia coli bnum: b0928; MultiFun: Metabolism 1.1.3, 1.5.1.5.
   
 
  0.841
Your Current Organism:
Blochmannia pennsylvanicus
NCBI taxonomy Id: 291272
Other names: C. Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus BPEN, Candidatus Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus strain BPEN
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