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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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sucBDihydrolipoamide succinyltransferase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (414 aa)    
Predicted Functional Partners:
sucA
2-oxoglutarate dehydrogenase E1 component; Ortholog to Escherichia coli bnum: b0726; MultiFun: Metabolism 1.3.4.
 0.999
lpdA
Dihydrolipoyl dehydrogenase; Ortholog to Escherichia coli bnum: b0116; MultiFun: Metabolism 1.1.1.20, 1.1.3.5, 1.3.3, 1.3.4, 1.3.6, 1.3.7, 1.7.17, 1.7.21.
 0.998
sucC
succinyl-CoA synthetase, beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.998
sucD
succinyl-CoA synthetase, alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.998
sdhA
Succinate dehydrogenase catalytic and flavoprotein subunit; Ortholog to Escherichia coli bnum: b0723; MultiFun: Metabolism 1.3.4, 1.3.6, 1.4.1; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 
 0.975
sdhB
Succinate dehydrogenase iron-sulfur protein; Ortholog to Escherichia coli bnum: b0724; MultiFun: Metabolism 1.3.4, 1.3.6, 1.4.1.
  
 
 0.968
aceE
Pyruvate dehydrogenase, decarboxylase subunit (E1), thiamin-binding; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.845
nuoCD
NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
   
   0.785
sdhC
Succinate dehydrogenase cytochrome b-556 subunit; Ortholog to Escherichia coli bnum: b0721; MultiFun: Cell structure 6.1; Metabolism 1.3.4, 1.3.6, 1.4.1, 1.4.3, 1.6.15.1.
  
  
 0.752
prsA
Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.741
Your Current Organism:
Blochmannia pennsylvanicus
NCBI taxonomy Id: 291272
Other names: C. Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus BPEN, Candidatus Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus strain BPEN
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