Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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tolBTolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (453 aa)    
Predicted Functional Partners:
pal
Pal; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 0.997
tolQ
TolQ; Inner membrane protein required for outer membrane integrity, uptake of group A colicins and phage DNA; ortholog to Escherichia coli bnum: b0737; MultiFun: Cell structure 6.1.
 
  
 0.988
ybgF
Putative periplasmic protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family.
 
  
 0.987
tolR
TolR; Role in outer membrane integrity, uptake of group A colicins (TonB-independent), and phage DNA; ortholog to Escherichia coli bnum: b0738; MultiFun: Cell structure 6.1.
 
  
 0.953
tonB
Energy transducer; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 0.892
tolA
TolA; Required for outer membrane integrity, uptake of group A colicins, role in translocation of filamenous phage DNA to cytoplasm, role in surface expression of O-antigen; ortholog to Escherichia coli bnum: b0739; MultiFun: Cell structure 6.1; Metabolism 1.6.3.1.
 
   0.867
yaeT
Outer membrane protein precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.
  
  
 0.754
surA
Peptidyl-prolyl cis-trans isomerase; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
  
  
 0.752
lolE
Transport protein of outer membrane lipoproteins (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b1118; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.106.
  
     0.656
lolC
Transport protein of outer membrane lipoproteins (ABC superfamily, membrane); Ortholog to Escherichia coli bnum: b1116; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.106.
  
     0.583
Your Current Organism:
Blochmannia pennsylvanicus
NCBI taxonomy Id: 291272
Other names: C. Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus BPEN, Candidatus Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus strain BPEN
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