Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sufDSufD; Required for stability of iron-sulfur component of FhuF; ortholog to Escherichia coli bnum: b1681; MultiFun: Metabolism 1.7.19. (429 aa)    
Predicted Functional Partners:
sufB
Putative transport protein associated with Fe-S cluster assembly; Ortholog to Escherichia coli bnum: b1683; MultiFun: Information transfer 2.3.4.
 
 
0.999
sufC
Putative transport protein associated with Fe-S cluster assembly (ABC superfamily, atp_bind); Ortholog to Escherichia coli bnum: b1682; MultiFun: Transport 4.3.A.1.a.
 
 
 0.999
sufS
Selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
 
 
 0.991
sufE
SufE; Ortholog to Escherichia coli bnum: b1679; MultiFun: Regulation 3.1.3.
 
 
 0.976
sufA
Fe-S cluster assembly protein; Ortholog to Escherichia coli bnum: b1684; MultiFun: Metabolism 1.7.19; Belongs to the HesB/IscA family.
 
 
 0.880
gntY
Membrane-bound protein in GNT I transport system; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
 
 0.526
yadR
Conserved hypothetical protein; Required for insertion of 4Fe-4S clusters for at least IspG.
   
 
 0.497
ycfM
Putative fibronectin-binding protein; Ortholog to Escherichia coli bnum: b1105.
  
     0.449
ygfZ
Putative aminomethyltransferase; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family.
  
   
 0.425
Your Current Organism:
Blochmannia pennsylvanicus
NCBI taxonomy Id: 291272
Other names: C. Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus BPEN, Candidatus Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus strain BPEN
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