| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| guaA | guaB | BPEN_546 | BPEN_547 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | gutQ | BPEN_546 | BPEN_474 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | 0.845 |
| guaA | hisB | BPEN_546 | BPEN_480 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Histidinol-phosphatase; Bifunctional; ortholog to Escherichia coli bnum: b2022; MultiFun: Metabolism 1.5.1.16; imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.560 |
| guaA | prsA | BPEN_546 | BPEN_356 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.828 |
| guaA | ribD | BPEN_546 | BPEN_240 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Pyrimidine deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.736 |
| guaA | rpsM | BPEN_546 | BPEN_220 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 30S ribosomal subunit protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. | 0.613 |
| guaA | trpC | BPEN_546 | BPEN_441 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Indole-3-glycerolphosphate synthetase; Bifunctional; ortholog to Escherichia coli bnum: b1262; MultiFun: Metabolism 1.5.1.15; N-(5-phosphoribosyl)anthranilate isomerase; Belongs to the TrpC family. | 0.623 |
| guaB | guaA | BPEN_547 | BPEN_546 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | gutQ | BPEN_547 | BPEN_474 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | 0.630 |
| guaB | hisB | BPEN_547 | BPEN_480 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Histidinol-phosphatase; Bifunctional; ortholog to Escherichia coli bnum: b2022; MultiFun: Metabolism 1.5.1.16; imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.595 |
| guaB | prsA | BPEN_547 | BPEN_356 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.805 |
| guaB | ribD | BPEN_547 | BPEN_240 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Pyrimidine deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.768 |
| guaB | rpsM | BPEN_547 | BPEN_220 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 30S ribosomal subunit protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. | 0.870 |
| guaB | trpC | BPEN_547 | BPEN_441 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Indole-3-glycerolphosphate synthetase; Bifunctional; ortholog to Escherichia coli bnum: b1262; MultiFun: Metabolism 1.5.1.15; N-(5-phosphoribosyl)anthranilate isomerase; Belongs to the TrpC family. | 0.672 |
| gutQ | guaA | BPEN_474 | BPEN_546 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.845 |
| gutQ | guaB | BPEN_474 | BPEN_547 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.630 |
| gutQ | hisB | BPEN_474 | BPEN_480 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | Histidinol-phosphatase; Bifunctional; ortholog to Escherichia coli bnum: b2022; MultiFun: Metabolism 1.5.1.16; imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.723 |
| gutQ | kdsA | BPEN_474 | BPEN_361 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | 3-deoxy-D-manno-octulosonic acid 8-P synthetase; Ortholog to Escherichia coli bnum: b1215; MultiFun: Cell structure 6.1, 6.2, 6.3, 6.7; Metabolism 1.6.5; Belongs to the KdsA family. | 0.907 |
| gutQ | kdsB | BPEN_474 | BPEN_387 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.925 |
| gutQ | prsA | BPEN_474 | BPEN_356 | Putative phosphosugar binding protein; Ortholog to Escherichia coli bnum: b2708; MultiFun: Cell structure 6.7; Regulation 3.1.4. | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.673 |