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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
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metBCystathionine gamma-synthase; Ortholog to Escherichia coli bnum: b3939; MultiFun: Metabolism 1.1.3.7, 1.5.1.9, 1.7.30. (382 aa)    
Predicted Functional Partners:
metA
Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
  
 
 0.972
cysK
Cysteine synthase A; Ortholog to Escherichia coli bnum: b2414; MultiFun: Metabolism 1.5.1.12; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 0.966
metF
5,10 methylenetetrahydrofolate reductase; Ortholog to Escherichia coli bnum: b3941; MultiFun: Metabolism 1.7.17; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.966
metC
Beta-cystathionase; Ortholog to Escherichia coli bnum: b3008; MultiFun: Metabolism 1.5.1.9.
  
 
 
0.955
thrA
Bifunctional; ortholog to Escherichia coli bnum: b0002; MultiFun: Metabolism 1.5.1.21, 1.5.1.8; homoserine dehydrogenase I, threonine sensitive; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.955
metE
5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.950
cysI
Sulfite reductase, beta subunit, NADPH-dependent hemoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 
 0.928
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
   
 0.908
cysJ
Sulfite reductase, alpha subunit (flavoprotein); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
   
 
 0.904
sufS
Selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
     
  0.900
Your Current Organism:
Blochmannia pennsylvanicus
NCBI taxonomy Id: 291272
Other names: C. Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus BPEN, Candidatus Blochmannia pennsylvanicus str. BPEN, Candidatus Blochmannia pennsylvanicus strain BPEN
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