| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AraD | SpeE | XOO2139 | XOO1588 | Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | Spermidine synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.713 |
| AraD | metK | XOO2139 | XOO3791 | Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.681 |
| AraD | mtnA | XOO2139 | XOO2407 | Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | Initiation factor eIF-2B; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.999 |
| AraD | mtnC | XOO2139 | XOO2137 | Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | Enolase-phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. | 0.999 |
| AraD | speD | XOO2139 | XOO4157 | Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | S-adenosyl methionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.785 |
| AraD | speE | XOO2139 | XOO0219 | Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.876 |
| SpeE | AraD | XOO1588 | XOO2139 | Spermidine synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.713 |
| SpeE | metK | XOO1588 | XOO3791 | Spermidine synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.716 |
| SpeE | mtnA | XOO1588 | XOO2407 | Spermidine synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Initiation factor eIF-2B; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.731 |
| SpeE | mtnC | XOO1588 | XOO2137 | Spermidine synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Enolase-phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. | 0.742 |
| SpeE | speD | XOO1588 | XOO4157 | Spermidine synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | S-adenosyl methionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.943 |
| SpeE | speE | XOO1588 | XOO0219 | Spermidine synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.720 |
| SsnA | XOO1598 | XOO2703 | XOO1598 | Cytosine deaminase and related metal-dependent hydrolases; Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the multicopper oxidase YfiH/RL5 family. | 0.900 |
| SsnA | mtnA | XOO2703 | XOO2407 | Cytosine deaminase and related metal-dependent hydrolases; Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline. | Initiation factor eIF-2B; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.440 |
| SsnA | speE | XOO2703 | XOO0219 | Cytosine deaminase and related metal-dependent hydrolases; Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.910 |
| XOO1598 | SsnA | XOO1598 | XOO2703 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the multicopper oxidase YfiH/RL5 family. | Cytosine deaminase and related metal-dependent hydrolases; Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline. | 0.900 |
| XOO1598 | mtnA | XOO1598 | XOO2407 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the multicopper oxidase YfiH/RL5 family. | Initiation factor eIF-2B; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.901 |
| XOO1598 | speE | XOO1598 | XOO0219 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the multicopper oxidase YfiH/RL5 family. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.900 |
| XOO2176 | speA | XOO2176 | XOO0220 | Beta-alanine synthetase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. | 0.712 |
| XOO2176 | speE | XOO2176 | XOO0219 | Beta-alanine synthetase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.945 |