| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysB | glyA | XOO0777 | XOO3860 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |
| cysB | metB | XOO0777 | XOO0778 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Cystathionine gamma-lyase-like protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.999 |
| cysB | metB-2 | XOO0777 | XOO1818 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Cystathionine gamma-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.991 |
| cysB | metE | XOO0777 | XOO4333 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.929 |
| cysB | metH | XOO0777 | XOO2074 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 5-methyltetrahydrofolate-homocysteine methyl transferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.923 |
| cysB | metH2 | XOO0777 | XOO2073 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.919 |
| cysB | nodQ | XOO0777 | XOO3396 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | ATP sulfurylase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.964 |
| cysB | rtxA | XOO0777 | XOO1390 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | RtxA; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.969 |
| cysB | sahH | XOO0777 | XOO3798 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.946 |
| cysB | trpA | XOO0777 | XOO3251 | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.919 |
| glyA | cysB | XOO3860 | XOO0777 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.946 |
| glyA | metE | XOO3860 | XOO4333 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.564 |
| glyA | metH | XOO3860 | XOO2074 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5-methyltetrahydrofolate-homocysteine methyl transferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.920 |
| glyA | metH2 | XOO3860 | XOO2073 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.920 |
| glyA | sahH | XOO3860 | XOO3798 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.545 |
| glyA | trpA | XOO3860 | XOO3251 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.926 |
| metB | cysB | XOO0778 | XOO0777 | Cystathionine gamma-lyase-like protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.999 |
| metB | metB-2 | XOO0778 | XOO1818 | Cystathionine gamma-lyase-like protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Cystathionine gamma-synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.907 |
| metB | metE | XOO0778 | XOO4333 | Cystathionine gamma-lyase-like protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.948 |
| metB | metH | XOO0778 | XOO2074 | Cystathionine gamma-lyase-like protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 5-methyltetrahydrofolate-homocysteine methyl transferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.937 |