Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (520 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.996
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.995
ilvE
Branched-chain amino acid aminotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.
  
 0.995
ilvD
Dihydroxy-acid dehydratase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the IlvD/Edd family.
 
 
 0.982
ilvG
Acetolactate synthase isozyme II large subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.
 
 
 0.970
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
 
 
 0.942
acs
Acetyl coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.930
atoB
acetoacetyl-CoA thiolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.925
yfcY
acyl-CoA thiolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.925
poxB
Pyruvate dehydrogenase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the TPP enzyme family.
 
 
 0.920
Your Current Organism:
Xanthomonas oryzae
NCBI taxonomy Id: 291331
Other names: X. oryzae pv. oryzae KACC 10331, Xanthomonas oryzae pv. oryzae KACC 10331, Xanthomonas oryzae pv. oryzae str. KACC 10331, Xanthomonas oryzae pv. oryzae strain KACC 10331
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