| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AmpD | ampG | XOO2445 | XOO0510 | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Signal transducer; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.694 |
| AmpD | anmK | XOO2445 | XOO0512 | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.796 |
| AmpD | mrsA | XOO2445 | XOO3249 | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Phosphohexose mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.512 |
| AmpD | nagZ | XOO2445 | XOO1867 | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | N-acetyl-beta-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.796 |
| AmpD-2 | ampG | XOO4100 | XOO0510 | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Signal transducer; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.828 |
| AmpD-2 | anmK | XOO4100 | XOO0512 | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.898 |
| AmpD-2 | mpl | XOO4100 | XOO0964 | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | UDP-N-acetylmuramate-L-alanine ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.525 |
| AmpD-2 | mrsA | XOO4100 | XOO3249 | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Phosphohexose mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.582 |
| AmpD-2 | nagZ | XOO4100 | XOO1867 | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | N-acetyl-beta-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.884 |
| XOO1866 | deoD | XOO1866 | XOO1869 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.494 |
| XOO1866 | hpt | XOO1866 | XOO1868 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Hypoxanthine-guanine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.655 |
| XOO1866 | nagZ | XOO1866 | XOO1867 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | N-acetyl-beta-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.655 |
| ampG | AmpD | XOO0510 | XOO2445 | Signal transducer; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.694 |
| ampG | AmpD-2 | XOO0510 | XOO4100 | Signal transducer; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.828 |
| ampG | anmK | XOO0510 | XOO0512 | Signal transducer; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.803 |
| ampG | mpl | XOO0510 | XOO0964 | Signal transducer; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | UDP-N-acetylmuramate-L-alanine ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.427 |
| ampG | nagZ | XOO0510 | XOO1867 | Signal transducer; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | N-acetyl-beta-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.864 |
| anmK | AmpD | XOO0512 | XOO2445 | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.796 |
| anmK | AmpD-2 | XOO0512 | XOO4100 | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Negative regulator of beta-lactamase expression; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.898 |
| anmK | ampG | XOO0512 | XOO0510 | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Signal transducer; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.803 |