| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TDO2 | kynU | XOO4075 | XOO2428 | Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.992 |
| TDO2 | trpA | XOO4075 | XOO3251 | Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.801 |
| UbiH | XOO2425 | XOO2429 | XOO2425 | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | Predicted membrane protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.428 |
| UbiH | XOO2426 | XOO2429 | XOO2426 | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.428 |
| UbiH | haaO | XOO2429 | XOO2424 | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.901 |
| UbiH | kynU | XOO2429 | XOO2428 | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.997 |
| XOO2425 | UbiH | XOO2425 | XOO2429 | Predicted membrane protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.428 |
| XOO2425 | XOO2426 | XOO2425 | XOO2426 | Predicted membrane protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.935 |
| XOO2425 | haaO | XOO2425 | XOO2424 | Predicted membrane protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.749 |
| XOO2425 | kynU | XOO2425 | XOO2428 | Predicted membrane protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.713 |
| XOO2425 | yadF | XOO2425 | XOO2423 | Predicted membrane protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.581 |
| XOO2426 | UbiH | XOO2426 | XOO2429 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.428 |
| XOO2426 | XOO2425 | XOO2426 | XOO2425 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Predicted membrane protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.935 |
| XOO2426 | haaO | XOO2426 | XOO2424 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.749 |
| XOO2426 | kynU | XOO2426 | XOO2428 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.713 |
| XOO2426 | yadF | XOO2426 | XOO2423 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.581 |
| catB | haaO | XOO0417 | XOO2424 | Catalase precursor; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the catalase family. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.900 |
| catB | katE | XOO0417 | XOO3423 | Catalase precursor; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the catalase family. | Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. | 0.919 |
| catB | kynU | XOO0417 | XOO2428 | Catalase precursor; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the catalase family. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.903 |
| catB | srpA | XOO0417 | XOO0447 | Catalase precursor; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the catalase family. | Catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. | 0.945 |