| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpA | clpP | XOO2553 | XOO1033 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.872 |
| clpA | clpS | XOO2553 | XOO2554 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.985 |
| clpA | dnaJ | XOO2553 | XOO2032 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.651 |
| clpA | dnaK | XOO2553 | XOO2031 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | DnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.769 |
| clpA | grpE | XOO2553 | XOO2030 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.697 |
| clpA | hspA | XOO2553 | XOO0909 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | Low molecular weight heat shock protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the small heat shock protein (HSP20) family. | 0.734 |
| clpA | minC | XOO2553 | XOO3530 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | Cell division inhibitor; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. | 0.604 |
| clpA | panC | XOO2553 | XOO2363 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | Pantoate-beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.615 |
| clpA | panD | XOO2553 | XOO2361 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.637 |
| clpA | yegD | XOO2553 | XOO1892 | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | Heat shock protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.751 |
| clpP | clpA | XOO1033 | XOO2553 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | 0.872 |
| clpP | clpS | XOO1033 | XOO2554 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.910 |
| clpP | dnaJ | XOO1033 | XOO2032 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.587 |
| clpP | dnaK | XOO1033 | XOO2031 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.769 |
| clpP | grpE | XOO1033 | XOO2030 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.729 |
| clpS | clpA | XOO2554 | XOO2553 | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | 0.985 |
| clpS | clpP | XOO2554 | XOO1033 | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.910 |
| dnaJ | clpA | XOO2032 | XOO2553 | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | ATP-dependent Clp protease subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ClpA/ClpB family. | 0.651 |
| dnaJ | clpP | XOO2032 | XOO1033 | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.587 |
| dnaJ | dnaK | XOO2032 | XOO2031 | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | DnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |