| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | guaA | XOO2717 | XOO2195 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | 0.864 |
| apt | hpt | XOO2717 | XOO1868 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.444 |
| apt | surE | XOO2717 | XOO2956 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.924 |
| cmk | guaA | XOO2179 | XOO2195 | Cytidylate kinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | 0.625 |
| cmk | pyrH | XOO2179 | XOO1974 | Cytidylate kinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.660 |
| cmk | surE | XOO2179 | XOO2956 | Cytidylate kinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.923 |
| dgt | surE | XOO4247 | XOO2956 | Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs. | Survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.924 |
| dut | surE | XOO0497 | XOO2956 | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.926 |
| guaA | apt | XOO2195 | XOO2717 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.864 |
| guaA | cmk | XOO2195 | XOO2179 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | Cytidylate kinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.625 |
| guaA | guaB | XOO2195 | XOO2194 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | hpt | XOO2195 | XOO1868 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | Hypoxanthine-guanine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.970 |
| guaA | pyrF | XOO2195 | XOO0247 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.719 |
| guaA | pyrH | XOO2195 | XOO1974 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.814 |
| guaA | surE | XOO2195 | XOO2956 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | Survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.968 |
| guaB | guaA | XOO2194 | XOO2195 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | hpt | XOO2194 | XOO1868 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypoxanthine-guanine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.927 |
| guaB | surE | XOO2194 | XOO2956 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.920 |
| hpt | apt | XOO1868 | XOO2717 | Hypoxanthine-guanine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.444 |
| hpt | guaA | XOO1868 | XOO2195 | Hypoxanthine-guanine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | 0.970 |