| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ERG9 | ispA | XOO2700 | XOO3299 | Phytoene/squalene synthetase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | 0.611 |
| ERG9 | ispB | XOO2700 | XOO1438 | Phytoene/squalene synthetase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Octaprenyl-diphosphate synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | 0.548 |
| XOO4875 | ispA | XOO4875 | XOO3299 | Hypothetical protein; Putative; ORF located using FrameD. | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | 0.557 |
| XOO4875 | mesJ | XOO4875 | XOO3297 | Hypothetical protein; Putative; ORF located using FrameD. | Cell cycle protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.407 |
| XOO4875 | phoA | XOO4875 | XOO3296 | Hypothetical protein; Putative; ORF located using FrameD. | Alkaline phosphatase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the alkaline phosphatase family. | 0.457 |
| XOO4875 | xseB | XOO4875 | XOO3298 | Hypothetical protein; Putative; ORF located using FrameD. | Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.408 |
| dxs | ispA | XOO2017 | XOO3299 | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | 0.750 |
| dxs | lytB | XOO2017 | XOO1628 | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.888 |
| dxs | uppS | XOO2017 | XOO1972 | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.452 |
| ispA | ERG9 | XOO3299 | XOO2700 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Phytoene/squalene synthetase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.611 |
| ispA | XOO4875 | XOO3299 | XOO4875 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Hypothetical protein; Putative; ORF located using FrameD. | 0.557 |
| ispA | dxs | XOO3299 | XOO2017 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.750 |
| ispA | ispB | XOO3299 | XOO1438 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Octaprenyl-diphosphate synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | 0.925 |
| ispA | lytB | XOO3299 | XOO1628 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.945 |
| ispA | mesJ | XOO3299 | XOO3297 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Cell cycle protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.842 |
| ispA | phoA | XOO3299 | XOO3296 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Alkaline phosphatase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the alkaline phosphatase family. | 0.661 |
| ispA | uppS | XOO3299 | XOO1972 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.970 |
| ispA | xseA | XOO3299 | XOO2737 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.679 |
| ispA | xseB | XOO3299 | XOO3298 | Geranyltranstransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.932 |
| ispB | ERG9 | XOO1438 | XOO2700 | Octaprenyl-diphosphate synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the FPP/GGPP synthase family. | Phytoene/squalene synthetase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.548 |