| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CumB-2 | XOO0570 | XOO3720 | XOO0570 | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.448 |
| CumB-2 | XOO1742 | XOO3720 | XOO1742 | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Inactive homolog of metal-dependent proteases, putative molecular chaperone; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.407 |
| CumB-2 | birA | XOO3720 | XOO0428 | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Biotin acetyl-CoA-carboxylase synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.837 |
| CumB-2 | hisI | XOO3720 | XOO2262 | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the N-terminal section; belongs to the PRA-CH family. | 0.879 |
| CumB-2 | rlmM | XOO3720 | XOO3721 | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. | 0.848 |
| XOO0570 | CumB-2 | XOO0570 | XOO3720 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.448 |
| XOO1742 | CumB-2 | XOO1742 | XOO3720 | Inactive homolog of metal-dependent proteases, putative molecular chaperone; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.407 |
| XOO1742 | birA | XOO1742 | XOO0428 | Inactive homolog of metal-dependent proteases, putative molecular chaperone; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Biotin acetyl-CoA-carboxylase synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.921 |
| XOO1742 | hisI | XOO1742 | XOO2262 | Inactive homolog of metal-dependent proteases, putative molecular chaperone; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the N-terminal section; belongs to the PRA-CH family. | 0.697 |
| birA | CumB-2 | XOO0428 | XOO3720 | Biotin acetyl-CoA-carboxylase synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.837 |
| birA | XOO1742 | XOO0428 | XOO1742 | Biotin acetyl-CoA-carboxylase synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Inactive homolog of metal-dependent proteases, putative molecular chaperone; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.921 |
| hisI | CumB-2 | XOO2262 | XOO3720 | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the N-terminal section; belongs to the PRA-CH family. | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.879 |
| hisI | XOO1742 | XOO2262 | XOO1742 | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the N-terminal section; belongs to the PRA-CH family. | Inactive homolog of metal-dependent proteases, putative molecular chaperone; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.697 |
| rlmM | CumB-2 | XOO3721 | XOO3720 | Conserved hypothetical protein; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. | Cytosine/adenosine deaminases; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.848 |