| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CirA-6 | XOO3857 | XOO3861 | XOO3857 | Outer membrane receptor proteins, mostly Fe transport; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Acetyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.427 |
| CirA-6 | XOO3859 | XOO3861 | XOO3859 | Outer membrane receptor proteins, mostly Fe transport; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Hypothetical protein; Putative; ORF located using Glimmer/Genemark. | 0.427 |
| CirA-6 | glyA | XOO3861 | XOO3860 | Outer membrane receptor proteins, mostly Fe transport; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.453 |
| CirA-6 | nrdR | XOO3861 | XOO3858 | Outer membrane receptor proteins, mostly Fe transport; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.427 |
| CirA-6 | ribD | XOO3861 | XOO3856 | Outer membrane receptor proteins, mostly Fe transport; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Riboflavin-specific deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.427 |
| XOO3857 | CirA-6 | XOO3857 | XOO3861 | Acetyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Outer membrane receptor proteins, mostly Fe transport; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.427 |
| XOO3857 | XOO3859 | XOO3857 | XOO3859 | Acetyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Hypothetical protein; Putative; ORF located using Glimmer/Genemark. | 0.781 |
| XOO3857 | glyA | XOO3857 | XOO3860 | Acetyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.738 |
| XOO3857 | nrdR | XOO3857 | XOO3858 | Acetyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.787 |
| XOO3857 | ribD | XOO3857 | XOO3856 | Acetyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Riboflavin-specific deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.809 |
| XOO3859 | CirA-6 | XOO3859 | XOO3861 | Hypothetical protein; Putative; ORF located using Glimmer/Genemark. | Outer membrane receptor proteins, mostly Fe transport; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.427 |
| XOO3859 | XOO3857 | XOO3859 | XOO3857 | Hypothetical protein; Putative; ORF located using Glimmer/Genemark. | Acetyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.781 |
| XOO3859 | glyA | XOO3859 | XOO3860 | Hypothetical protein; Putative; ORF located using Glimmer/Genemark. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.729 |
| XOO3859 | nrdR | XOO3859 | XOO3858 | Hypothetical protein; Putative; ORF located using Glimmer/Genemark. | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.782 |
| XOO3859 | ribD | XOO3859 | XOO3856 | Hypothetical protein; Putative; ORF located using Glimmer/Genemark. | Riboflavin-specific deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.809 |
| glyA | CirA-6 | XOO3860 | XOO3861 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Outer membrane receptor proteins, mostly Fe transport; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.453 |
| glyA | XOO3857 | XOO3860 | XOO3857 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Acetyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.738 |
| glyA | XOO3859 | XOO3860 | XOO3859 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Hypothetical protein; Putative; ORF located using Glimmer/Genemark. | 0.729 |
| glyA | nrdR | XOO3860 | XOO3858 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.844 |
| glyA | ribD | XOO3860 | XOO3856 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Riboflavin-specific deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.823 |