TDO2 protein (Xanthomonas oryzae) - STRING interaction network

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TDO2

Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (326 aa)

Predicted Functional Partners:

kynU

0.992

trpA

0.801

trpB

0.800

XOO0876

0.654

XOO3316

0.654

XOO4071

0.619

iorA

0.616

SIR2

0.615

pdhA

0.613

nucH

0.574

Your Current Organism:

Xanthomonas oryzae

NCBI taxonomy Id: 291331
Other names: X. oryzae pv. oryzae KACC 10331, Xanthomonas oryzae pv. oryzae KACC 10331, Xanthomonas oryzae pv. oryzae str. KACC 10331, Xanthomonas oryzae pv. oryzae strain KACC 10331

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIR2	TDO2	XOO4347	XOO4075	NAD-dependent protein deacetylases, SIR2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily.	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.615
TDO2	SIR2	XOO4075	XOO4347	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	NAD-dependent protein deacetylases, SIR2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily.	0.615
TDO2	XOO0876	XOO4075	XOO0876	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily.	0.654
TDO2	XOO3316	XOO4075	XOO3316	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	0.654
TDO2	XOO4071	XOO4075	XOO4071	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	4-hydroxyphenylpyruvate dioxygenase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	0.619
TDO2	iorA	XOO4075	XOO4505	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Indolepyruvate ferredoxin oxidoreductase chain alpha; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	0.616
TDO2	kynU	XOO4075	XOO2428	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively.	0.992
TDO2	nucH	XOO4075	XOO4076	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Nuclease; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	0.574
TDO2	pdhA	XOO4075	XOO4077	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Pyruvate dehydrogenase E1 alpha subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	0.613
TDO2	trpA	XOO4075	XOO3251	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.801
TDO2	trpB	XOO4075	XOO3252	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.800
XOO0876	TDO2	XOO0876	XOO4075	Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily.	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.654
XOO3316	TDO2	XOO3316	XOO4075	Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.654
XOO4071	TDO2	XOO4071	XOO4075	4-hydroxyphenylpyruvate dioxygenase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.619
iorA	TDO2	XOO4505	XOO4075	Indolepyruvate ferredoxin oxidoreductase chain alpha; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.616
kynU	TDO2	XOO2428	XOO4075	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively.	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.992
kynU	trpA	XOO2428	XOO3251	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively.	Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.673
nucH	TDO2	XOO4076	XOO4075	Nuclease; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.574
nucH	pdhA	XOO4076	XOO4077	Nuclease; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	Pyruvate dehydrogenase E1 alpha subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	0.572
pdhA	TDO2	XOO4077	XOO4075	Pyruvate dehydrogenase E1 alpha subunit; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark.	Tryptophan 2,3-dioxygenase (vermilion); Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.613

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