node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASH2L | ENSVURP00010001880 | ENSVURP00010013422 | ENSVURP00010001880 | B30.2/SPRY domain-containing protein. | FHA domain-containing protein. | 0.961 |
ASH2L | KDM6A | ENSVURP00010013422 | ENSVURP00010003940 | B30.2/SPRY domain-containing protein. | Uncharacterized protein. | 0.990 |
ASH2L | KDM6B | ENSVURP00010013422 | ENSVURP00010004682 | B30.2/SPRY domain-containing protein. | Lysine demethylase 6B. | 0.988 |
ASH2L | RBBP5 | ENSVURP00010013422 | ENSVURP00010016926 | B30.2/SPRY domain-containing protein. | WD_REPEATS_REGION domain-containing protein. | 0.999 |
ASH2L | TP53BP1 | ENSVURP00010013422 | ENSVURP00010008027 | B30.2/SPRY domain-containing protein. | Uncharacterized protein. | 0.613 |
ATM | ENSVURP00010001880 | ENSVURP00010018477 | ENSVURP00010001880 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | FHA domain-containing protein. | 0.978 |
ATM | KDM6A | ENSVURP00010018477 | ENSVURP00010003940 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Uncharacterized protein. | 0.448 |
ATM | MRE11 | ENSVURP00010018477 | ENSVURP00010013682 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.997 |
ATM | NBN | ENSVURP00010018477 | ENSVURP00010006975 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.997 |
ATM | RAD50 | ENSVURP00010018477 | ENSVURP00010007541 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Zinc-hook domain-containing protein. | 0.996 |
ATM | TP53BP1 | ENSVURP00010018477 | ENSVURP00010008027 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Uncharacterized protein. | 0.994 |
ENSVURP00010001880 | ASH2L | ENSVURP00010001880 | ENSVURP00010013422 | FHA domain-containing protein. | B30.2/SPRY domain-containing protein. | 0.961 |
ENSVURP00010001880 | ATM | ENSVURP00010001880 | ENSVURP00010018477 | FHA domain-containing protein. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.978 |
ENSVURP00010001880 | KDM6A | ENSVURP00010001880 | ENSVURP00010003940 | FHA domain-containing protein. | Uncharacterized protein. | 0.967 |
ENSVURP00010001880 | KDM6B | ENSVURP00010001880 | ENSVURP00010004682 | FHA domain-containing protein. | Lysine demethylase 6B. | 0.967 |
ENSVURP00010001880 | MRE11 | ENSVURP00010001880 | ENSVURP00010013682 | FHA domain-containing protein. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.959 |
ENSVURP00010001880 | NBN | ENSVURP00010001880 | ENSVURP00010006975 | FHA domain-containing protein. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.973 |
ENSVURP00010001880 | PWWP2A | ENSVURP00010001880 | ENSVURP00010005259 | FHA domain-containing protein. | PWWP domain containing 2A. | 0.964 |
ENSVURP00010001880 | RAD50 | ENSVURP00010001880 | ENSVURP00010007541 | FHA domain-containing protein. | Zinc-hook domain-containing protein. | 0.953 |
ENSVURP00010001880 | RBBP5 | ENSVURP00010001880 | ENSVURP00010016926 | FHA domain-containing protein. | WD_REPEATS_REGION domain-containing protein. | 0.961 |