STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrB_2DNA topoisomerase IV subunit B. (623 aa)    
Predicted Functional Partners:
gyrA_1
DNA topoisomerase IV subunit A.
 
 0.985
gyrA_2
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 0.976
coaD
Putative phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
       0.836
ctpB
Carboxy-terminal processing protease; Belongs to the peptidase S41A family.
  
    0.757
polA
Putative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.744
gadB
Glutamate decarboxylase; Belongs to the group II decarboxylase family.
     
 0.711
CUN08508.1
Uncharacterised protein.
   
 
 0.691
CUM88909.1
Uncharacterised protein.
     
 0.684
dnaK2
Putative chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.663
dnaN
Putative DNA polymerase III beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiat [...]
 
 
 0.655
Your Current Organism:
Bacteroides salyersiae
NCBI taxonomy Id: 291644
Other names: ATCC BAA-997, B. salyersiae, Bacteroides salyersae, Bacteroides salyersiae corrig. Song et al. 2005, Bacteroides sp. WAL 10018, CCUG 48945, DSM 18765, JCM 12988, WAL 10018
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