STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANCCAN_27157MutS_IV domain-containing protein. (97 aa)    
Predicted Functional Partners:
ANCCAN_20429
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
   
 0.991
ANCCAN_17154
DNA mismatch repair protein.
  
 0.981
ANCCAN_14265
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.972
ANCCAN_12353
Mlh1_C domain-containing protein.
  
 0.946
ANCCAN_12350
DNA mismatch repair protein.
  
 0.946
ANCCAN_12349
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein.
  
 0.946
ANCCAN_22047
XPG protein.
   
 0.927
ANCCAN_22045
XPG protein.
   
 0.927
ANCCAN_16620
Uncharacterized protein.
   
 0.927
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.918
Your Current Organism:
Ancylostoma caninum
NCBI taxonomy Id: 29170
Other names: A. caninum, dog hookworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.