STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANCCAN_247075'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (366 aa)    
Predicted Functional Partners:
ANCCAN_03166
Phosphodiesterase.
     
 0.940
ANCCAN_01790
AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
     
 0.932
ANCCAN_02177
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
     
 0.924
ANCCAN_21585
Putative adenine phosphoribosyltransferase.
     
 0.918
ANCCAN_04041
Orotate phosphoribosyltransferase.
     
 0.918
ANCCAN_00834
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
    
  0.916
ANCCAN_29340
PDEase domain-containing protein.
     
 0.915
ANCCAN_28618
3'5'-cyclic nucleotide phosphodiesterase; Belongs to the cyclic nucleotide phosphodiesterase family.
     
 0.915
ANCCAN_11303
Phosphodiesterase.
     
 0.915
ANCCAN_14475
Thymidylate_kin domain-containing protein.
   
 
 0.914
Your Current Organism:
Ancylostoma caninum
NCBI taxonomy Id: 29170
Other names: A. caninum, dog hookworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.