STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DICVIV_06139Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxid [...] (102 aa)    
Predicted Functional Partners:
DICVIV_12059
PDZ/DHR/GLGF domain protein; Belongs to the MAGUK family.
    
 0.997
DICVIV_12058
Protein kinase domain-containing protein.
    
 0.997
DICVIV_04670
Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]
    
 0.978
DICVIV_00141
PDZ/DHR/GLGF domain protein; Belongs to the MAGUK family.
    
 0.811
DICVIV_00140
PDZ/DHR/GLGF domain protein.
    
 0.811
DICVIV_05637
Phosphotyrosine interaction domain protein.
    
 0.771
DICVIV_05638
Uncharacterized protein.
    
 0.771
DICVIV_07064
Uncharacterized protein.
    
 0.763
DICVIV_07066
Kinase domain protein.
    
 0.763
DICVIV_07063
Calcium/calmodulin dependent protein kinase II Association.
    
 0.763
Your Current Organism:
Dictyocaulus viviparus
NCBI taxonomy Id: 29172
Other names: D. viviparus, Dictyocaulus sp. AMP-2014, bovine lungworm
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