node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOI82439.1 | AOI82442.1 | WI67_08250 | WI67_08275 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.428 |
AOI82439.1 | AOI82458.1 | WI67_08250 | WI67_08360 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobalamin biosynthesis protein CbiG; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.818 |
AOI82439.1 | AOI82460.1 | WI67_08250 | WI67_08370 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-8X methylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.793 |
AOI82439.1 | AOI82464.1 | WI67_08250 | WI67_08395 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | cobalt-precorrin-6A reductase; CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.823 |
AOI82439.1 | AOI84133.1 | WI67_08250 | WI67_08385 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-6Y C5,15-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.890 |
AOI82439.1 | CobI | WI67_08250 | WI67_08365 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.844 |
AOI82439.1 | CobM | WI67_08250 | WI67_08400 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-4 C(11)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.842 |
AOI82439.1 | cbiA | WI67_08250 | WI67_08240 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.887 |
AOI82439.1 | cbiD | WI67_08250 | WI67_08390 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | cobalt-precorrin-6A synthase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.799 |
AOI82439.1 | cobQ | WI67_08250 | WI67_13215 | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.513 |
AOI82442.1 | AOI82439.1 | WI67_08275 | WI67_08250 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.428 |
AOI82442.1 | AOI82458.1 | WI67_08275 | WI67_08360 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobalamin biosynthesis protein CbiG; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.887 |
AOI82442.1 | AOI82460.1 | WI67_08275 | WI67_08370 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-8X methylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.869 |
AOI82442.1 | AOI82464.1 | WI67_08275 | WI67_08395 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | cobalt-precorrin-6A reductase; CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.853 |
AOI82442.1 | AOI84133.1 | WI67_08275 | WI67_08385 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-6Y C5,15-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.951 |
AOI82442.1 | CobI | WI67_08275 | WI67_08365 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.860 |
AOI82442.1 | CobM | WI67_08275 | WI67_08400 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-4 C(11)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.763 |
AOI82442.1 | cbiA | WI67_08275 | WI67_08240 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.920 |
AOI82442.1 | cbiD | WI67_08275 | WI67_08390 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | cobalt-precorrin-6A synthase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.787 |
AOI82442.1 | cobQ | WI67_08275 | WI67_13215 | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.620 |