Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DM42_4053
annotation not available (246 aa)
Predicted Functional Partners:
DM42_4051
annotation not available
0.973
DM42_4049
annotation not available
0.965
DM42_4052
Conserved hypothetical protein
0.960
DM42_4050
PRTRC_F: PRTRC system F family protein
0.845
DM42_4054
Conserved hypothetical protein
0.845
DM42_4048
PRTRC_E: PRTRC system E domain protein
0.837
DM42_4055
annotation not available
0.826
thiS
thiS: thiamine biosynthesis protein ThiS
0.630
WI67_09850
Molybdopterin synthase sulfur carrier subunit; Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin