node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOI84686.1 | fumA | WI67_19425 | WI67_11925 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.958 |
AOI84686.1 | fumC | WI67_19425 | WI67_05275 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Class II fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.962 |
AOI84686.1 | gltA | WI67_19425 | WI67_21865 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.893 |
AOI84686.1 | icd | WI67_19425 | WI67_13625 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.499 |
AOI84686.1 | icd_2 | WI67_19425 | WI67_13620 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. | 0.445 |
AOI84686.1 | maeB_1 | WI67_19425 | WI67_01330 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malic enzymes family. | 0.928 |
AOI84686.1 | maeB_2 | WI67_19425 | WI67_02905 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
AOI84686.1 | mdh | WI67_19425 | WI67_21830 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.976 |
AOI84686.1 | pckG | WI67_19425 | WI67_24765 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.400 |
fumA | AOI84686.1 | WI67_11925 | WI67_19425 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.958 |
fumA | fumC | WI67_11925 | WI67_05275 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Class II fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.977 |
fumA | gltA | WI67_11925 | WI67_21865 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.961 |
fumA | icd | WI67_11925 | WI67_13625 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.966 |
fumA | icd_2 | WI67_11925 | WI67_13620 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. | 0.508 |
fumA | maeB_1 | WI67_11925 | WI67_01330 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malic enzymes family. | 0.958 |
fumA | maeB_2 | WI67_11925 | WI67_02905 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.958 |
fumA | mdh | WI67_11925 | WI67_21830 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.996 |
fumA | pckG | WI67_11925 | WI67_24765 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.434 |
fumC | AOI84686.1 | WI67_05275 | WI67_19425 | Class II fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.962 |
fumC | fumA | WI67_05275 | WI67_11925 | Class II fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.977 |