cobalt-precorrin-6A reductase; CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; Derived by automated computational analysis using gene prediction method: Protein Homology.

precorrin-6Y C5,15-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.

Cobalamin biosynthesis protein CbiG; Catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3; Derived by automated computational analysis using gene prediction method: Protein Homology.

cobalt-precorrin-6A synthase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

precorrin-8X methylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology.

Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.

Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A.

Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.

Adenosylcobinamide kinase/adenosylcobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.