| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cmk | guaA | WI67_05055 | WI67_10820 | Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.578 |
| cmk | guaB | WI67_05055 | WI67_10830 | Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Guanosine monophosphate reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.447 |
| cmk | pyrF | WI67_05055 | WI67_02880 | Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Orotidine 5'-phosphate decarboxylase; Type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.695 |
| cmk | pyrH | WI67_05055 | WI67_10965 | Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.676 |
| cmk | surE | WI67_05055 | WI67_09710 | Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.921 |
| cmk | upp | WI67_05055 | WI67_12450 | Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.675 |
| dut | guaB | WI67_13565 | WI67_10830 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Guanosine monophosphate reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.463 |
| dut | pyrH | WI67_13565 | WI67_10965 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.428 |
| dut | surE | WI67_13565 | WI67_09710 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
| dut | thyA | WI67_13565 | WI67_05255 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.966 |
| guaA | cmk | WI67_10820 | WI67_05055 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.578 |
| guaA | guaB | WI67_10820 | WI67_10830 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Guanosine monophosphate reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | purH | WI67_10820 | WI67_03225 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.911 |
| guaA | pyrF | WI67_10820 | WI67_02880 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Orotidine 5'-phosphate decarboxylase; Type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.526 |
| guaA | pyrH | WI67_10820 | WI67_10965 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.768 |
| guaA | surE | WI67_10820 | WI67_09710 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.948 |
| guaA | thyA | WI67_10820 | WI67_05255 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.489 |
| guaA | upp | WI67_10820 | WI67_12450 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.952 |
| guaB | cmk | WI67_10830 | WI67_05055 | Guanosine monophosphate reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.447 |
| guaB | dut | WI67_10830 | WI67_13565 | Guanosine monophosphate reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.463 |