| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AOI82038.1 | AOI86871.1 | WI67_06040 | WI67_31620 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Citrate synthase/methylcitrate synthase; Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.415 |
| AOI82038.1 | AcoB | WI67_06040 | WI67_09785 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.902 |
| AOI82038.1 | LpdA | WI67_06040 | WI67_11555 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.965 |
| AOI82038.1 | aceE | WI67_06040 | WI67_11565 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.940 |
| AOI82038.1 | aceE-2 | WI67_06040 | WI67_27530 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.940 |
| AOI82038.1 | acoA | WI67_06040 | WI67_09790 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.824 |
| AOI82038.1 | acoC_1 | WI67_06040 | WI67_09780 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetoin dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.967 |
| AOI82038.1 | gltA | WI67_06040 | WI67_21865 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.415 |
| AOI82038.1 | lpdA | WI67_06040 | WI67_07490 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.910 |
| AOI82038.1 | sucC | WI67_06040 | WI67_14215 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.529 |
| AOI86871.1 | AOI82038.1 | WI67_31620 | WI67_06040 | Citrate synthase/methylcitrate synthase; Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.415 |
| AOI86871.1 | AcoB | WI67_31620 | WI67_09785 | Citrate synthase/methylcitrate synthase; Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.418 |
| AOI86871.1 | LpdA | WI67_31620 | WI67_11555 | Citrate synthase/methylcitrate synthase; Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.814 |
| AOI86871.1 | acoC_1 | WI67_31620 | WI67_09780 | Citrate synthase/methylcitrate synthase; Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetoin dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.958 |
| AOI86871.1 | gltA | WI67_31620 | WI67_21865 | Citrate synthase/methylcitrate synthase; Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.917 |
| AOI86871.1 | lpdA | WI67_31620 | WI67_07490 | Citrate synthase/methylcitrate synthase; Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.415 |
| AOI86871.1 | sucC | WI67_31620 | WI67_14215 | Citrate synthase/methylcitrate synthase; Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.762 |
| AcoB | AOI82038.1 | WI67_09785 | WI67_06040 | Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.902 |
| AcoB | AOI86871.1 | WI67_09785 | WI67_31620 | Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Citrate synthase/methylcitrate synthase; Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.418 |
| AcoB | LpdA | WI67_09785 | WI67_11555 | Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.997 |
