iscR protein (Burkholderia cepacia) - STRING interaction network

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[Homology]

Score

iscR

Rrf2 family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)

Predicted Functional Partners:

iscU

0.973

iscS_1

0.962

iscS_2

0.959

hscB

0.943

AOI84608.1

0.913

iscA

0.875

fdx

0.756

iscX

0.686

hscA

0.585

erpA

0.572

Your Current Organism:

Burkholderia cepacia

NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, Burkholderia sp. Bp7081, Burkholderia sp. Bp7091, Burkholderia sp. Bp7098, Burkholderia sp. Bp7108, Burkholderia sp. Bp7432, Burkholderia sp. LK29, Burkholderia sp. NCIM 5465, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOI84608.1	erpA	WI67_18950	WI67_03175	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	0.655
AOI84608.1	fdx	WI67_18950	WI67_11485	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.811
AOI84608.1	hscA	WI67_18950	WI67_11490	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.761
AOI84608.1	hscB	WI67_18950	WI67_11495	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	0.887
AOI84608.1	iscA	WI67_18950	WI67_11500	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron-sulfur cluster assembly protein IscA; Forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HesB/IscA family.	0.863
AOI84608.1	iscR	WI67_18950	WI67_11515	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Rrf2 family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.913
AOI84608.1	iscU	WI67_18950	WI67_11505	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Scaffolding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	0.993
AOI84608.1	iscX	WI67_18950	WI67_11480	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fe-S assembly protein IscX; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.589
erpA	AOI84608.1	WI67_03175	WI67_18950	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.655
erpA	fdx	WI67_03175	WI67_11485	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.612
erpA	hscA	WI67_03175	WI67_11490	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	Molecular chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.683
erpA	hscB	WI67_03175	WI67_11495	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	0.808
erpA	iscR	WI67_03175	WI67_11515	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	Rrf2 family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.572
erpA	iscS_1	WI67_03175	WI67_20705	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.601
erpA	iscS_2	WI67_03175	WI67_11510	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.601
erpA	iscU	WI67_03175	WI67_11505	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	Scaffolding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	0.899
erpA	iscX	WI67_03175	WI67_11480	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	Fe-S assembly protein IscX; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.577
fdx	AOI84608.1	WI67_11485	WI67_18950	2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.811
fdx	erpA	WI67_11485	WI67_03175	2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters.	0.612
fdx	hscA	WI67_11485	WI67_11490	2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.971

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