STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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Textmining
[Homology]
Score
mngR_4Histidine utilization repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)    
Predicted Functional Partners:
hutH_2
Catalyzes the degradation of histidine to urocanate and ammmonia; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.942
hutI
Imidazolonepropionase; Catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.920
hutU
Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
 
  
 0.908
AOI83068.1
Histidine utilization protein HutD; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.869
HutF
Catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.796
HutG
N-formylglutamate deformylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.741
rpoE_1
RNA polymerase subunit sigma; Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily.
      
 0.582
AOI86451.1
GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.582
HpaR
MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.569
moaD
Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.547
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, Burkholderia sp. Bp7081, Burkholderia sp. Bp7091, Burkholderia sp. Bp7098, Burkholderia sp. Bp7108, Burkholderia sp. Bp7432, Burkholderia sp. LK29, Burkholderia sp. NCIM 5465, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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