| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AOI81572.1 | coaX | WI67_03475 | WI67_15495 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.480 |
| AOI81572.1 | lptC | WI67_03475 | WI67_14915 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | LPS export ABC transporter periplasmic protein LptC; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.767 |
| AOI83008.1 | coaX | WI67_11405 | WI67_15495 | Hsp33 chaperonin; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.471 |
| AOI83760.1 | birA | WI67_15500 | WI67_15490 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Biotin--protein ligase; Catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.537 |
| AOI83760.1 | coaX | WI67_15500 | WI67_15495 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.537 |
| CoaBC | birA | WI67_13560 | WI67_15490 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Biotin--protein ligase; Catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.402 |
| CoaBC | coaD | WI67_13560 | WI67_15015 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.955 |
| CoaBC | coaX | WI67_13560 | WI67_15495 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.930 |
| CoaBC | nnrD | WI67_13560 | WI67_10165 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-spec [...] | 0.474 |
| CoaBC | panC | WI67_13560 | WI67_13195 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.975 |
| CoaBC | panD | WI67_13560 | WI67_13200 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Aspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.801 |
| birA | AOI83760.1 | WI67_15490 | WI67_15500 | Biotin--protein ligase; Catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.537 |
| birA | CoaBC | WI67_15490 | WI67_13560 | Biotin--protein ligase; Catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.402 |
| birA | coaX | WI67_15490 | WI67_15495 | Biotin--protein ligase; Catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.938 |
| birA | nnrD | WI67_15490 | WI67_10165 | Biotin--protein ligase; Catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-spec [...] | 0.485 |
| birA | panC | WI67_15490 | WI67_13195 | Biotin--protein ligase; Catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.470 |
| coaD | CoaBC | WI67_15015 | WI67_13560 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.955 |
| coaD | coaX | WI67_15015 | WI67_15495 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.962 |
| coaX | AOI81572.1 | WI67_15495 | WI67_03475 | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.480 |
| coaX | AOI83008.1 | WI67_15495 | WI67_11405 | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | Hsp33 chaperonin; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. | 0.471 |
