STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABF62888.1Thiamine pyrophosphate enzyme-like TPP binding region; Belongs to the TPP enzyme family. (592 aa)    
Predicted Functional Partners:
ABF63607.1
Acetolactate synthase, small subunit.
 
 
 0.940
ABF62892.1
Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.925
ABF62889.1
Transcriptional regulator, GntR family.
 
    0.813
ABF62887.1
Hypothetical protein.
       0.763
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.695
ilvD
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
  
 0.668
ABF65555.1
Glutamate synthase (NADPH) large subunit.
  
  
 0.575
edd
6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family.
 
  
 0.546
ABF64306.1
Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) Phosphate acetyltransferase.
  
  
 0.533
ABF65609.1
Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) Phosphate acetyltransferase.
  
  
 0.533
Your Current Organism:
Ruegeria sp. TM1040
NCBI taxonomy Id: 292414
Other names: R. sp. TM1040, Silicibacter sp. TM1040
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.