node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABF62888.1 | ABF63607.1 | TM1040_0155 | TM1040_0874 | Thiamine pyrophosphate enzyme-like TPP binding region; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.940 |
ABF62888.1 | ilvC | TM1040_0155 | TM1040_2303 | Thiamine pyrophosphate enzyme-like TPP binding region; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.695 |
ABF62888.1 | leuA | TM1040_0155 | TM1040_2282 | Thiamine pyrophosphate enzyme-like TPP binding region; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.406 |
ABF63607.1 | ABF62888.1 | TM1040_0874 | TM1040_0155 | Acetolactate synthase, small subunit. | Thiamine pyrophosphate enzyme-like TPP binding region; Belongs to the TPP enzyme family. | 0.940 |
ABF63607.1 | ABF63608.1 | TM1040_0874 | TM1040_0875 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
ABF63607.1 | ABF63887.1 | TM1040_0874 | TM1040_1154 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.941 |
ABF63607.1 | ABF64263.1 | TM1040_0874 | TM1040_1530 | Acetolactate synthase, small subunit. | Thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 0.994 |
ABF63607.1 | ABF64665.1 | TM1040_0874 | TM1040_1932 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.994 |
ABF63607.1 | ABF65432.1 | TM1040_0874 | TM1040_2700 | Acetolactate synthase, small subunit. | Pyridoxal-5'-phosphate-dependent enzyme beta subunit. | 0.955 |
ABF63607.1 | ABF65743.1 | TM1040_0874 | TM1040_3011 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase. | 0.955 |
ABF63607.1 | ilvA | TM1040_0874 | TM1040_2885 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.955 |
ABF63607.1 | ilvC | TM1040_0874 | TM1040_2303 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
ABF63607.1 | leuA | TM1040_0874 | TM1040_2282 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.940 |
ABF63608.1 | ABF63607.1 | TM1040_0875 | TM1040_0874 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
ABF63608.1 | ABF63887.1 | TM1040_0875 | TM1040_1154 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.914 |
ABF63608.1 | ABF64263.1 | TM1040_0875 | TM1040_1530 | Acetolactate synthase, large subunit. | Thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 0.924 |
ABF63608.1 | ABF64665.1 | TM1040_0875 | TM1040_1932 | Acetolactate synthase, large subunit. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.924 |
ABF63608.1 | ABF65432.1 | TM1040_0875 | TM1040_2700 | Acetolactate synthase, large subunit. | Pyridoxal-5'-phosphate-dependent enzyme beta subunit. | 0.923 |
ABF63608.1 | ABF65743.1 | TM1040_0875 | TM1040_3011 | Acetolactate synthase, large subunit. | L-threonine ammonia-lyase. | 0.923 |
ABF63608.1 | ilvA | TM1040_0875 | TM1040_2885 | Acetolactate synthase, large subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.945 |