node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABF63194.1 | surE | TM1040_0461 | TM1040_1791 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 5'-nucleotidase / 3'-nucleotidase / exopolyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.915 |
ABF63194.1 | tdk | TM1040_0461 | TM1040_0626 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase. | 0.976 |
ABF63194.1 | thyA | TM1040_0461 | TM1040_1729 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.972 |
ABF63906.1 | ABF63918.1 | TM1040_1173 | TM1040_1185 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | metF protein-like protein. | 0.930 |
ABF63906.1 | ABF64433.1 | TM1040_1173 | TM1040_1700 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.912 |
ABF63906.1 | ABF64461.1 | TM1040_1173 | TM1040_1728 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.905 |
ABF63906.1 | ABF65125.1 | TM1040_1173 | TM1040_2393 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Glycine cleavage system T protein. | 0.924 |
ABF63906.1 | folD | TM1040_1173 | TM1040_2356 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
ABF63906.1 | glyA | TM1040_1173 | TM1040_1579 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
ABF63906.1 | thyA | TM1040_1173 | TM1040_1729 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.910 |
ABF63918.1 | ABF63906.1 | TM1040_1185 | TM1040_1173 | metF protein-like protein. | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.930 |
ABF63918.1 | ABF64433.1 | TM1040_1185 | TM1040_1700 | metF protein-like protein. | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.935 |
ABF63918.1 | ABF65125.1 | TM1040_1185 | TM1040_2393 | metF protein-like protein. | Glycine cleavage system T protein. | 0.910 |
ABF63918.1 | folD | TM1040_1185 | TM1040_2356 | metF protein-like protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.918 |
ABF63918.1 | glyA | TM1040_1185 | TM1040_1579 | metF protein-like protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
ABF63918.1 | thyA | TM1040_1185 | TM1040_1729 | metF protein-like protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.915 |
ABF64433.1 | ABF63906.1 | TM1040_1700 | TM1040_1173 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.912 |
ABF64433.1 | ABF63918.1 | TM1040_1700 | TM1040_1185 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | metF protein-like protein. | 0.935 |
ABF64433.1 | ABF65125.1 | TM1040_1700 | TM1040_2393 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein. | 0.912 |
ABF64433.1 | folD | TM1040_1700 | TM1040_2356 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.949 |