STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhADehydrogenase complex, E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (333 aa)    
Predicted Functional Partners:
Tbd_0652
Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase E3 component.
 0.999
Tbd_0654
Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.999
Tbd_1189
Dihydrolipoamide succinyltransferase.
 0.995
Tbd_1556
Oxaloacetate decarboxylase, alpha subunit.
    
 0.949
Tbd_2468
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
    
 0.949
Tbd_1472
Putative pyridine nucleotide-disulfide oxidoreductase.
 
 0.940
pykA
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.934
Tbd_1181
Malate dehydrogenase (oxaloacetate-decarboxylating).
   
 
 0.927
merA
Mercuric reductase MerA; Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 
 0.924
Tbd_0618
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
    
 0.916
Your Current Organism:
Thiobacillus denitrificans ATCC 25259
NCBI taxonomy Id: 292415
Other names: T. denitrificans ATCC 25259, Thiobacillus denitrificans str. ATCC 25259, Thiobacillus denitrificans strain ATCC 25259
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