Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sucDsuccinyl-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
Tbd_1185
Succinate dehydrogenase; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 0.994
Tbd_1189
Dihydrolipoamide succinyltransferase.
 0.992
Tbd_1182
Succinate dehydrogenase cytochrome b-556 subunit.
  
 
 0.987
Tbd_1184
Succinate dehydrogenase; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 0.982
Tbd_1188
2-oxoglutarate dehydrogenase, E1 component.
 0.980
Tbd_1183
Succinate dehydrogenase, cytochrome b subunit.
  
 
 0.958
Tbd_0652
Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase E3 component.
  
 
 0.946
Tbd_1187
Citrate synthase I; Belongs to the citrate synthase family.
  
 
 0.913
Tbd_2468
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
  
 
 0.913
Your Current Organism:
Thiobacillus denitrificans ATCC 25259
NCBI taxonomy Id: 292415
Other names: T. denitrificans ATCC 25259, Thiobacillus denitrificans str. ATCC 25259, Thiobacillus denitrificans strain ATCC 25259
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