node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tbd_0222 | Tbd_2011 | Tbd_0222 | Tbd_2011 | Conserved hypothetical protein; Belongs to the DnaA family. | HAD-superfamily hydrolase. | 0.678 |
Tbd_2010 | Tbd_2011 | Tbd_2010 | Tbd_2011 | Hypothetical protein. | HAD-superfamily hydrolase. | 0.636 |
Tbd_2011 | Tbd_0222 | Tbd_2011 | Tbd_0222 | HAD-superfamily hydrolase. | Conserved hypothetical protein; Belongs to the DnaA family. | 0.678 |
Tbd_2011 | Tbd_2010 | Tbd_2011 | Tbd_2010 | HAD-superfamily hydrolase. | Hypothetical protein. | 0.636 |
Tbd_2011 | hisA | Tbd_2011 | Tbd_1709 | HAD-superfamily hydrolase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.832 |
Tbd_2011 | hisB | Tbd_2011 | Tbd_1711 | HAD-superfamily hydrolase. | Imidazoleglycerol-phosphate dehydratase. | 0.868 |
Tbd_2011 | hisD | Tbd_2011 | Tbd_1713 | HAD-superfamily hydrolase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.731 |
Tbd_2011 | hisE | Tbd_2011 | Tbd_1706 | HAD-superfamily hydrolase. | phosphoribosyl-ATP pyrophosphohydrolase. | 0.687 |
Tbd_2011 | hisF | Tbd_2011 | Tbd_1708 | HAD-superfamily hydrolase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.904 |
Tbd_2011 | hisH | Tbd_2011 | Tbd_1710 | HAD-superfamily hydrolase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.856 |
Tbd_2011 | hisI | Tbd_2011 | Tbd_1707 | HAD-superfamily hydrolase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.845 |
Tbd_2011 | hisZ | Tbd_2011 | Tbd_0606 | HAD-superfamily hydrolase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.868 |
hisA | Tbd_2011 | Tbd_1709 | Tbd_2011 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | HAD-superfamily hydrolase. | 0.832 |
hisA | hisB | Tbd_1709 | Tbd_1711 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.996 |
hisA | hisD | Tbd_1709 | Tbd_1713 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.993 |
hisA | hisE | Tbd_1709 | Tbd_1706 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-ATP pyrophosphohydrolase. | 0.996 |
hisA | hisF | Tbd_1709 | Tbd_1708 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisH | Tbd_1709 | Tbd_1710 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Tbd_1709 | Tbd_1707 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | Tbd_1709 | Tbd_0606 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.930 |