| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Tbd_0020 | mscL | Tbd_0020 | Tbd_2455 | Trk system potassium uptake protein TrkA. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.427 |
| Tbd_1570 | mscL | Tbd_1570 | Tbd_2455 | Cyclic nucleotide-binding domain (cNMP-BD) protein. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.453 |
| Tbd_1570 | polA | Tbd_1570 | Tbd_2453 | Cyclic nucleotide-binding domain (cNMP-BD) protein. | DNA polymerase A; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.445 |
| Tbd_1570 | recA | Tbd_1570 | Tbd_2197 | Cyclic nucleotide-binding domain (cNMP-BD) protein. | RecA DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.443 |
| Tbd_2454 | mscL | Tbd_2454 | Tbd_2455 | Outer membrane protein. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.577 |
| Tbd_2457 | dusB | Tbd_2457 | Tbd_2456 | Transcriptional Regulator, Fis family; Belongs to the transcriptional regulatory Fis family. | Dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | 0.975 |
| Tbd_2457 | mscL | Tbd_2457 | Tbd_2455 | Transcriptional Regulator, Fis family; Belongs to the transcriptional regulatory Fis family. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.515 |
| Tbd_2457 | polA | Tbd_2457 | Tbd_2453 | Transcriptional Regulator, Fis family; Belongs to the transcriptional regulatory Fis family. | DNA polymerase A; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.711 |
| Tbd_2457 | purH | Tbd_2457 | Tbd_2458 | Transcriptional Regulator, Fis family; Belongs to the transcriptional regulatory Fis family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase bifunctional enzyme. | 0.827 |
| dusB | Tbd_2457 | Tbd_2456 | Tbd_2457 | Dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | Transcriptional Regulator, Fis family; Belongs to the transcriptional regulatory Fis family. | 0.975 |
| dusB | mscL | Tbd_2456 | Tbd_2455 | Dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.535 |
| dusB | polA | Tbd_2456 | Tbd_2453 | Dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | DNA polymerase A; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.570 |
| dusB | purH | Tbd_2456 | Tbd_2458 | Dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase bifunctional enzyme. | 0.799 |
| metK | mscL | Tbd_2521 | Tbd_2455 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.831 |
| metK | polA | Tbd_2521 | Tbd_2453 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | DNA polymerase A; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.413 |
| metK | recA | Tbd_2521 | Tbd_2197 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | RecA DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.509 |
| metK | ribH | Tbd_2521 | Tbd_2191 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.936 |
| mscL | Tbd_0020 | Tbd_2455 | Tbd_0020 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Trk system potassium uptake protein TrkA. | 0.427 |
| mscL | Tbd_1570 | Tbd_2455 | Tbd_1570 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Cyclic nucleotide-binding domain (cNMP-BD) protein. | 0.453 |
| mscL | Tbd_2454 | Tbd_2455 | Tbd_2454 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Outer membrane protein. | 0.577 |
