STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysGuroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (479 aa)    
Predicted Functional Partners:
Tbd_2567
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.996
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.995
cbiA
Cobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
   
 0.988
hemE
Uroporphyrinogen decarboxylase HemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.976
cysC
Sulfate adenylyltranferase, adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate.
  
  
 0.972
sat
ATP-sulfurylase; Belongs to the sulfate adenylyltransferase family.
  
  
 0.935
Tbd_2717
Nitroreductase-like protein.
    
 0.925
Tbd_0189
Delta-aminolevulinic acid dehydratase, porphobilinogen synthase; Belongs to the ALAD family.
 
  
 0.923
Tbd_2566
uroporphyrin-III C-methyltransferase.
     
 0.918
Tbd_0271
Putative dioxygenase ferredoxin subunit.
  
  
 0.884
Your Current Organism:
Thiobacillus denitrificans ATCC 25259
NCBI taxonomy Id: 292415
Other names: T. denitrificans ATCC 25259, Thiobacillus denitrificans str. ATCC 25259, Thiobacillus denitrificans strain ATCC 25259
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.