STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STH1827Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (355 aa)    
Predicted Functional Partners:
STH230
Glutamate synthase large subunit.
  
 
 0.978
STH1830
Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
 
  
 
0.956
STH2161
Branched-chain alpha-keto acid dehydrogenase E1 beta subunit.
  
 
 0.938
STH2162
Branched-chain alpha-keto acid dehydrogenase E1 alpha subunit.
  
 
 0.935
STH583
Branched-chain alpha-keto acid dehydrogenase E1 alpha subunit.
  
 
 0.935
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
   
 0.920
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.919
STH1988
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
   
 
 0.910
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
   
 
 0.910
buk-2
Branched-chain-fatty-acid kinase; Belongs to the acetokinase family.
  
  
 0.900
Your Current Organism:
Symbiobacterium thermophilum
NCBI taxonomy Id: 292459
Other names: S. thermophilum IAM 14863, Symbiobacterium thermophilum IAM 14863, Symbiobacterium thermophilum str. IAM 14863, Symbiobacterium thermophilum strain IAM 14863
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